Obagi360 Retinol 0.5

Obagi360 Retinol 0.5 is a retinol cream from Obagi Medical for fine lines and wrinkles, uneven tone and blemishes, including for sensitive skin.

Apply one pearl-sized pump to the face and massage until absorbed. Use once daily in the evening.

Mild redness or peeling can occur; if irritated, use every other night, and wear SPF 30 or higher daily.

Obagi says mild redness, peeling or irritation may occur and is temporary. Limit use to every other night, or as tolerated, then return to daily use.

Retinol 0.5 is the lower strength in the Obagi360 line, so it is the usual starting point. Once your skin tolerates it nightly, ask us whether moving up to Retinol 1.0 makes sense.

Obagi360 Retinol 0.5 is $80 at Obagi’s list price as of November 2026. Obagi sets the price, so the price at checkout is the current one.

The Naderi Center is an authorized Obagi Medical provider with offices in Reston, Virginia and Chevy Chase, Maryland. Order through the Shop button on this page: you check out on Obagi’s official store and it ships to your door anywhere in the DC area, including McLean, Great Falls, Arlington, Bethesda and Potomac.

Ask us first. Before and after lasers, peels, microneedling or surgery, we will tell you when to pause active products and when to restart them.