Is Juvederm made of any bacterium or proteins? in Virginia, Washington D.C. and Maryland Is Juvederm made of any bacterium or proteins? If so, is it common to have an allergic reaction to it? Answer: Juvederm is made up mainly of Hyaluronic Acid molecules like Restylane and Perlane. The risk of allergy is very minimal but allergic reactions have been described in literature.